Zinc-Related Magnetic Isotope Effect in the Enzymatic ATP Synthesis: A Medicinal Potential of the Nuclear Spin Selectivity Phenomena

doi:ijmmas.2010.34.37

eISSN: 1994-4624 / ISSN: 1813-176x

International Journal of Molecular Medicine and Advance Sciences

2010, Volume 6, Issue 3 : 34-37 doi: ijmmas.2010.34.37

Research Article

Zinc-Related Magnetic Isotope Effect in the Enzymatic ATP Synthesis: A Medicinal Potential of the Nuclear Spin Selectivity Phenomena

DOI : ijmmas.2010.34.37

Published

June 30, 2005

Abstract

The rate of enzymatic ATP synthesis is shown to depend on the zinc isotopes. The ATP producing activities of creatine kinase and pyruvate kinase in which Zn2+ ions have magnetic nuclei 67Zn are found to be 2-6 times higher than that of enzymes in which Zn2+ ions have nonmagnetic nuclei 64Zn. The isolated rat heart muscle mitochondria exhibit a similar effect. An expression of this magnetic isotope effect in enzymatic ATP synthesis processed in the presence of Zn2+ ions is in a favor to the ion-radical mechanism of ATP production occurred within a high zinc concentration range. Both fundamental aspect and a possible pharmacological significance of the phenomenon described are under discussion.

Keywords

Hyper activation of the ATP synthesis

Magnetic isotope effects

Mitochondria function control

Phenomenon

Zn+2 ion

Nuclei

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

All papers should be submitted electronically. All submitted manuscripts must be original work that is not under submission at another journal or under consideration for publication in another form, such as a monograph or chapter of a book. Authors of submitted papers are obligated not to submit their paper for publication elsewhere until an editorial decision is rendered on their submission. Further, authors of accepted papers are prohibited from publishing the results in other publications that appear before the paper is published in the Journal unless they receive approval for doing so from the Editor-In-Chief.

Int. J. Mol. Med. Adv. Sci. open access articles are licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. This license lets the audience to give appropriate credit, provide a link to the license, and indicate if changes were made and if they remix, transform, or build upon the material, they must distribute contributions under the same license as the original.

Recommended Articles

Outcomes of Primary Percutaneous Coronary Intervention in Rural vs. Urban Hospitals in Bangladesh

Mohammad Rahman,

Farhana Sultana,

Ahsan Habib,

Nusrat Jahan

26-30

Complication Rates of PCI in Patients With Renal Impairment

Aakash Verma,

Laila Hussain,

Rahman Siddiqui

1-4