Emergency angioplasty, a life-saving intervention in acute coronary syndromes (ACS), has traditionally relied on the femoral artery for vascular access. However, with advancements in catheterization techniques, radial access has gained prominence owing to reduced bleeding complications and early patient mobilization. This comparative study evaluates clinical outcomes, procedural efficiency, complication rates, hemodynamic stability, and post-procedural recovery metrics between radial and femoral access in emergency angioplasty. A sample of 520 ACS patients was analyzed over 24 months at a tertiary cardiac center. Statistical findings revealed that radial access significantly reduced major bleeding (2.5% vs. 8.9%, p<0.01), shortened recovery times, and improved patient comfort without compromising procedural success. The study concludes that radial access should be recommended as the primary approach in emergency settings, except in hemodynamic instability or complex multi-vessel interventions.