"Paraneoplasia as an essential system of involvement inherent to genetic attributes of neoplastic cellular proliferative events might actually involve an epigenetic process in a context of, however, systemic progression by the neoplasm. Indeed, a strict referential series of events as steps in systemic involvement of the patient by a proliferating and infiltrative neoplasm might simply constitute modes of how such a neoplasm
is, itself, a primarily systemic phenomenon with paradoxically focal manifestations that implicate however, progressive regional spread. In this sense, neoplasia might primarily constitute a process of systemic dimensions that is manifested also as a systemic phenomenon of paraneoplasia. In addition, one might speak of paraneoplastic syndromes as, for example, myasthenia gravis or endocrine manifestations, that parallel an associated neoplasm as a focal lesion of systemic dimensions. Indeed, genetic and epigenetic manifestations of neoplasia would involve different aspects of a phenomenon of systemic evolution that is not only manifested focally or regionally but is progressive mainly in terms of a focality that evolves in a strictly systemic context of genesis and epigenesis."