Atrial Septal Defect (ASD) device closure is an established minimally invasive alternative to surgical repair. Traditionally, these procedures are performed under general anesthesia (GA), but local anesthesia (LA) with conscious sedation is increasingly being preferred due to reduced complications, faster recovery, and lower procedural cost. This retrospective multi-center study compares clinical outcomes of ASD device closure performed under LA (n=340) vs GA (n=280) across a 6-year period. Primary outcomes include procedural success, hemodynamic stability, complications, fluoroscopy time, and hospital stay. Results indicate comparable success rates (LA 97.9%, GA 98.6%) but LA significantly reduced hospital stay (1.2 vs 2.7 days), anesthesia-related adverse events (1.8% vs 8.6%), and total cost. This study suggests that LA is a safe and cost-effective alternative for most adult ASD closures, though GA remains preferable in pediatric and anxious patients.