Healthcare workers (HCWs) represent the backbone of healthcare systems worldwide; however, they face numerous occupational hazards that threaten their physical, psychological, and social well-being. Occupational health risks among healthcare workers include biological exposures, musculoskeletal disorders, chemical hazards, radiation exposure, workplace violence, psychological stress, and burnout. These risks not only affect healthcare professionals but also compromise healthcare quality, patient safety, and organizational performance. This review comprehensively examines the prevalence, risk factors, health consequences, and preventive measures related to occupational hazards in healthcare settings. Evidence suggests that implementing comprehensive occupational health and safety programs, promoting workplace wellness, and strengthening institutional policies can significantly reduce occupational risks and improve workforce resilience.