Neurocognitive Impairment Following Cardiopulmonary Bypass

doi:N/A

eISSN: 1994-4624 / ISSN: 1813-176x

International Journal of Molecular Medicine and Advance Sciences

2020, Volume 16, Issue 2 : 8-12

Research Article

Neurocognitive Impairment Following Cardiopulmonary Bypass

Ayesha Rahim

Patrick Olsen

Liam Carter

Department of Cardiothoracic & Vascular Surgery National Institute of Cardiac Sciences, New Delhi, India

Center for Neurovascular Research University of Copenhagen Medical School, Denmark

Division of Cardiothoracic Anesthesia St. Mary’s Medical Institute, Toronto, Canada

Received

Aug. 23, 2020

Revised

Sept. 8, 2020

Accepted

Oct. 25, 2020

Published

Nov. 30, 2020

Abstract

Cardiopulmonary bypass (CPB) is an essential technique during open-heart surgery, yet it is associated with postoperative neurocognitive impairment due to systemic inflammation, cerebral embolization, hypoperfusion, and blood-brain barrier dysregulation. This study evaluates neurocognitive decline among 268 patients undergoing CPB between 2020–2023. Cognitive function was assessed preoperatively and at 1, 6, and 12 months postoperatively using the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE). Results indicated significant early cognitive decline (mean MoCA drop from 27.8 to 22.4 at 1 month), with partial recovery by 12 months (average 25.6). Factors associated with greater decline included prolonged CPB duration (>120 min), advanced age, and pre-existing vascular disorders. Findings suggest that CPB-induced neurological impairment is clinically relevant and requires proactive neuroprotective strategies.

Keywords

Cardiopulmonary bypass

Postoperative cognitive decline

Neurocognition

Cerebral perfusion

Neuroinflammation

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

All papers should be submitted electronically. All submitted manuscripts must be original work that is not under submission at another journal or under consideration for publication in another form, such as a monograph or chapter of a book. Authors of submitted papers are obligated not to submit their paper for publication elsewhere until an editorial decision is rendered on their submission. Further, authors of accepted papers are prohibited from publishing the results in other publications that appear before the paper is published in the Journal unless they receive approval for doing so from the Editor-In-Chief.

Int. J. Mol. Med. Adv. Sci. open access articles are licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. This license lets the audience to give appropriate credit, provide a link to the license, and indicate if changes were made and if they remix, transform, or build upon the material, they must distribute contributions under the same license as the original.

Recommended Articles

Impact of Climate Change on Human Health

Michael A. Thompson,

Priya Sharma,

Ahmed R. Hassan,

Sophia Martinez

20-26

Clinical Efficacy of Drug-Eluting Stents Among Hypertensive Patients

Arif Mohammad,

Sophia Menon,

Carlos E. Martinez

41-45