Severe mitral regurgitation (MR) is a progressive cardiac disorder characterized by the backflow of blood from the left ventricle into the left atrium due to structural or functional mitral valve insufficiency. Mitral valve clip therapy, also known as transcatheter edge-to-edge repair (TEER), has emerged as a minimally invasive alternative to surgical repair or replacement, particularly for high-risk and elderly patients. This paper evaluates the efficacy, clinical outcomes, safety profile, procedural success, and long-term function of mitral valve clip therapy compared to conventional surgical methods and medical therapy. Evidence suggests that clip therapy reduces MR severity, improves NYHA functional class, reduces hospitalization rates, and extends survival in selected patients. However, anatomical limitations and residual MR remain potential concerns.