Integral  ischemic  and  inflammatory  conditioning  influences  in  determining  responsiveness  of  cells  and  tissues  in  transforming  pathology  ranging  from  infection  to  neoplasia  to  tissue   atrophy would  in  various  ways  perhaps  help  delineate  pathways  of  pathologic  progressiveness   beyond simple  etiologic  considerations.    Indeed,   responsiveness   of   injured   cells,  tissues  and  organs  as  an inflammatory  series  of  pathways  in  a  conditioning  setting  induced  by  variable states of pre-existing or coincident  ischemia  might  perhaps  help  account  for  the  development of different patterns of pathologic progressiveness  in  cells and tissues.  Indeed, a system of neoplastic transformation would be distinct from one  of  active infection, of progressive tissue atrophy, or of evolving frank infarction, simply in terms of the nature  of  the   responsiveness  pathways  as  developing  in  injured  cells  and tissues in the first instance.  Ischemic  effect  would  itself  perhaps  prove  a  prime  mode  of  influence in determining the nature of such responsiveness  of  cells,  tissues,  and  organs  when  injured  in  ultimately    distinguishing     between    a pattern  of  active  infection  versus  one  of  neoplasia  or  of  atrophy  in  a  progressive  setting  of disease evolution and transformation.