"Evolving systems of developmental biology might implicate realized events that progress as cell
proliferation and spread. Metastases of tumor cells appear to constitute a further characterization of such
developmental systems in terms of how integrity of tissues is otherwise further maintained and supported by
various contributing cell groups. Component factors appear to constitute a further development in cell biology
that allow for the subsequent evolution of malignancy in terms of infiltration of a stroma that is proliferative
also. Blood stream spread and lymph node deposits are further characterized as trophic phenomena within
evolving contexts of either tumor cell proliferation or of stromal cell participation of such deposits. Only in terms
of such evolving cell biologic systems as proliferation and hematogeneous spread can one better understand
and delineate modes of interaction of proliferating tumor cells and stroma as integral representations of
developmental tissue and cell systems. Differentiation is a constituent event in the evolution of pathways of
development that allows for both characterization and phenotypic determination of events of malignant tumor
cell proliferation and spread."