An either/or integration of proliferative tumor cell events would perhaps relate to a stromal desmoplasia that strictly reflects also angiogenesis and metastatic spread. Indeed, it would be perhaps be in terms of a responsiveness to actively proliferating cells that one might define neoplastic cell infiltration and spread as simply an uncoupling of cell cycling and of gene expression. Indeed, a basic formula towards understanding neoplastic transformation might lie specifically with essential uncoupling of various phases of the cell division cycle and of the various forms of cell responsiveness conducive ultimately to an amplification of self-progressiveness. One might indeed recognize uncoupling of various systems of proliferative interaction as both arising and progressing in terms of neoplastic cell infiltration and metastatic spread. Even beyond simple equations of gene silencing and of programmed cell death, various mechanistic pathways of system uncoupling promote neoplastic progression in terms of transformation.