Wound healing activities of plant extract mixtures in combination with honey was studied on cutaneous excision wounds in rats. Three groups of male <I>Sprague Dawley</I> rats were used and all animals were experimentally wounded in the posterior neck area. Pure un-boiled honey was applied topically to wounds of Group 1 animals. Wounds of Group 2 rats were treated with honey in combination with 5% plant extract mixtures, and honey in combination with 10% plant extract mixtures was applied topically to wounds of Group 3 animals. The effects of vehicles on the rate of wound healing were assessed. Wounds treated with honey in combination with 10% plant extract mixtures were significantly (p&lt;0.05) accelerated wound healing compared to wounds treated by honey alone. These results strongly document the beneficial effects of 10% plant extract mixtures for the acceleration of wound healing process.