"Neurodegeneration constitutes a loss of neuronal cells in terms of ongoing injury to cell membranes
and organelles. A loss of membranous constituents of the cell appears to account for a process of cerebral
cortical atrophy consistent with a further injury to nuclei in the form of DNA fragmentation and induced
apoptosis. One might recognize the development of neurofilament aggregation and of beta-amyloid
fibrillogenesis in terms of a selective involvement of the neuronal cell body in the neurodegeneration.
Alzheimer`s disease constitutes a representation of onset dynamics with aging of the central nervous system
in the ongoing continuum of further injury to the neuronal cell. A spectrum of dynamic changes would involve
in particular a targeting of autophosphorylation systems based on membranes and constituting synaptic injury
as a primary site of action. Synapses and cell organelles are a constituent system of dynamic turnover
particularly susceptible to ongoing injury as represented and as further developed by such systems as protein
molecular misfolding and oxidative stress, within an overall context of cytokine and chemokine action."