Within a framework of operative control of cellular homeostasis one would necessarily have to conceptualize a system of mechanistic pathways that is essentially transformed as this affects organs and tissues within a given organism. Suppression would appear to perhaps constitute the main form of controlling influence governing not only such potential transformational events towards disease states but also the intrinsic operability of the genome as an operative system of the integral organism as a whole. It is perhaps in such terms that neoplasia and neurodegeneration would appear to constitute systems of de-suppression of such pathways as differentiation/de-differentiation and proliferative/non or anti-proliferative activity with neoplastic transformation, or with apoptosis/anti-apoptosis and cell necrosis in neurodegeneration.De- evolution in terms of desuppression of biologic and homeostatic systems of control might actually constitute the single integral substrate for pathobiologic transformation from a healthy to a diseased state of the organ and organism. A concept of intrinsic rhythmicity of evolution and de-evolution, of suppression and desuppression, or activation and de-activation, would appear to constitute a series of basic mechanistic pathways that would go beyond a simple concept of transformation of events and of attributes not only in the maintenance of homeostasis but also within the realm of the disease state. In such a system, one might in the final analysis have to consider a complex interplay of metabolic and mechanistic pathways that interactively participate at multiple different levels of operability in ensuring the switching on and off of induced effects within a system of identifiable form and function. In a final analysis, therefore, both biology and disease in molecular terms would have to take into consideration the essential attributes of constitutional change that both require suppression and desuppression, activation and de-activation, evolution and de-evolution in an overall process contrary to the concept of constancy of homeostatic control or of static maintenance of health.