Antimicrobial effect of uda (Xylopia aethopica) and nchuawu (Occimum gratissimum) on some pathogens: Proteus mirabilis, Esherichial coli, Staphylococcus aureus and Candida albicans were carried out. Different solvents used for the extraction of the plant were water (hot and cold) and ethanol. The antibacterial effect of Xylopia aethopica of its aqueous (cold) and (hot) showed inhibition on Proteus mirabilis, Staphylococcus aureus and Candida albicans with MIC of 0.0625 on Proteus mirabilis of aqueous cold and 0.25 of aqueous hot, 0.0625 on Staphylococcus aureus of aqueous cold and 0.0625 on aqueous hot, 0.25 on Candida albicans of aqueous cold extract and 0.5 on aqueous (hot) extract and no inhibition on Esherichial coli. Occimum gratissimum showed inhibition on Proteus mirabilis, Esherichial coli and Staphylococcus aureus of it`s ethanolic and aqueous extracts. Proteus mirabilis on ethanolic extract with the MIC of 0.5, Esherichia.coli with 0.125 and Staphylococcus aureus with 0.25. the aqueous cold extract on, Proteus mirabilis with MIC of 0.125 on Esherichial coli with 0.5 and on Staphylococcus aureus 0.25 while aqueous hot with Proteus mirabilis with 0.125, Esherichial coli with 0.25 and Staphylococcus aureus with 0.25 and no inhibition on Candida albicans. This justifies the therapeutic uses of Occimum gratissiumum and Xylopia aethopica. Further investigation can combine the plants extracts for possible synergetic effects.