Essential uncoupling of substrate metabolic and oxidative systems of supply and utilization by clones of neoplastic cells might correlate with various uncoupled phenomena of neoplastic cell proliferation and spread in specific patterns of carcinogenetic derivation and subsequent evolution. In this sense, the clonally based distributional patterns of intratumoral hypoxia and of various other pathobiologic effects of induced transformation ranging from angiogenesis to infiltrative spread of the neoplastic cells might constitute active modulation as exerted by active and passively acquired pathways of lost suppressor gene function. Indeed, one might speak of quantitative and qualitative systems of evolved influence that parallel each other and mirror fundamental uncoupling disturbances leading to a paradoxical series of systems characterized as patterned autonomous proliferation of malignant orimmortalized cells.